Human understanding

Human understanding of life and how we go about things will always be a complex topic. While Hume states "matters of fact" other people may want more scientific information and answers or even just information that is known. As Hume stated "We should in vain, therefore, attempt to demonstrate its falsehood". If we think about this why would want to prove something that we just "know" as false? Must we constantly question everything that surrounds us? Or can we just take what we have learned and know as fact and continue on with our lives.